GHK-Cu

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GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine. It is widely studied in biochemical and cellular research for its role in extracellular matrix regulation, gene expression signaling, and tissue remodeling pathways. Supplied strictly for laboratory research use only.

For research purposes only. Not for human consumption

Research Overview

GHK-Cu was first identified in human plasma and has since been studied extensively in molecular and cell biology research. Scientific literature describes its ability to bind copper ions and interact with cellular signaling pathways involved in collagen synthesis, angiogenesis, and antioxidant enzyme activity [1][2]. In vitro studies have shown that GHK-Cu can influence gene expression related to tissue regeneration, inflammation modulation, and cellular differentiation [3]. Due to its copper-chelating properties, GHK-Cu is also explored in research models examining metal ion homeostasis and redox balance at the cellular level.

Applications in Scientific Research

In laboratory and preclinical research settings, GHK-Cu is commonly used in studies related to skin biology, wound healing models, and connective tissue research. Published studies have investigated its role in fibroblast proliferation, extracellular matrix organization, and metalloproteinase regulation under controlled conditions [4]. Additional research explores GHK-Cu in neurobiological and oxidative stress models, focusing on its interaction with antioxidant pathways and cellular protection mechanisms [5][6]. These findings position GHK-Cu as a valuable reference compound for researchers studying tissue remodeling, copper-dependent signaling, and gene regulatory processes. This compound is not intended for human or veterinary use.

Referenced Citations

  1. Pickart L. “The human plasma copper-binding growth factor glycyl-L-histidyl-L-lysine.” Biochemical and Biophysical Research Communications.
    https://pubmed.ncbi.nlm.nih.gov/7081889/
  2. Pickart L., Thaler M.M. “Tripeptide copper complex stimulates wound healing.” Nature.
    https://pubmed.ncbi.nlm.nih.gov/6337163/
  3. Hong Y. et al. “Gene expression changes induced by the copper peptide GHK-Cu.” Journal of Biomolecular Structure & Dynamics.
    https://pubmed.ncbi.nlm.nih.gov/20228004/
  4. Maquart F.X. et al. “Stimulation of collagen synthesis in fibroblast cultures by copper peptides.” FEBS Letters.
    https://pubmed.ncbi.nlm.nih.gov/2561945/
  5. Pickart L. et al. “GHK-Cu and antioxidant enzyme activity.” Journal of Inorganic Biochemistry.
    https://pubmed.ncbi.nlm.nih.gov/15598544/
  6. Hostýnek J.J., Maibach H.I. “Copper in human biology and research.” Critical Reviews in Toxicology.
    https://pubmed.ncbi.nlm.nih.gov/12594245/
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