Research Overview
Ipamorelin was developed as part of a class of growth hormone secretagogues designed to stimulate growth hormone release via ghrelin receptor activation while minimizing interaction with other hormonal pathways [1]. Preclinical and molecular studies have examined its effects on GHSR-mediated signaling, intracellular calcium mobilization, and cyclic AMP pathways in pituitary cell models [2]. Due to its high receptor selectivity and short peptide structure, ipamorelin is frequently used in research focused on receptor specificity, structure–activity relationships, and comparative analysis of ghrelin mimetics [3].
Applications in Scientific Research
In laboratory and animal research models, ipamorelin is primarily studied within endocrinology, metabolism, and neuroendocrine research frameworks. Published literature explores its role in pulsatile growth hormone secretion, interactions with the growth hormone–insulin-like growth factor (GH–IGF) axis, and pituitary function under controlled experimental conditions [4]. Additional studies investigate ipamorelin in combination research models alongside GHRH analogs to examine synergistic receptor signaling mechanisms [5][6]. These findings position ipamorelin as a valuable reference compound for researchers studying ghrelin receptor biology and growth hormone regulatory systems. This compound is not intended for human or veterinary use.
Referenced Citations
- Raun K. et al. “Ipamorelin, a selective growth hormone secretagogue.” Journal of Endocrinology.
https://pubmed.ncbi.nlm.nih.gov/10443570/
- Van der Lely A.J. et al. “Growth hormone secretagogues: mechanisms of action.” Endocrine Reviews.
https://pubmed.ncbi.nlm.nih.gov/11370954/
- Bowers C.Y. “Growth hormone–releasing peptides and ghrelin mimetics.” Peptides.
https://pubmed.ncbi.nlm.nih.gov/12742069/
- Veldhuis J.D. et al. “Pulsatile growth hormone secretion and regulation.” Endocrine Reviews.
https://pubmed.ncbi.nlm.nih.gov/12794189/
- Merriam G.R. et al. “Combined GHRH and GHS effects on growth hormone secretion.” Journal of Clinical Endocrinology & Metabolism.
https://pubmed.ncbi.nlm.nih.gov/15181084/
- Bowers C.Y. et al. “Synergistic actions of GHRH analogs and GHS peptides.” Endocrinology.
https://pubmed.ncbi.nlm.nih.gov/10875263/