Research Overview
MOTS-C was identified as a bioactive peptide translated from a short open reading frame within mitochondrial 12S rRNA, highlighting its unique role in mitochondria-to-nucleus communication [1]. Preclinical studies demonstrate that MOTS-C can translocate to the nucleus under metabolic stress conditions and influence the expression of genes involved in cellular metabolism and homeostasis [2]. Research has focused on its interaction with AMP-activated protein kinase (AMPK) signaling pathways, positioning MOTS-C as a key molecule in studies of mitochondrial signaling and metabolic adaptation [3].
Applications in Scientific Research
In laboratory and animal research models, MOTS-C is primarily studied in metabolic biology, mitochondrial function, and cellular stress response frameworks. Published studies have examined its role in glucose utilization, lipid metabolism, and insulin signaling pathways under controlled experimental conditions [4]. Additional research explores MOTS-C in aging-related models, skeletal muscle metabolism studies, and exercise-induced metabolic adaptation research [5][6]. These findings have positioned MOTS-C as an important reference compound for researchers investigating mitochondrial peptides, energy homeostasis, and nucleus-mitochondria signaling mechanisms. This compound is intended solely for research and analytical purposes and is not approved for human or veterinary use.
Referenced Citations
- Lee C. et al. “Mitochondrial-derived peptides and their biological functions.” Trends in Endocrinology & Metabolism.
https://pubmed.ncbi.nlm.nih.gov/27553124/
- Kim K.H. et al. “The mitochondrial-derived peptide MOTS-C translocates to the nucleus to regulate metabolic homeostasis.” Cell Metabolism.
https://pubmed.ncbi.nlm.nih.gov/27050520/
- Lee C., Yen K., Cohen P. “Humanin and mitochondrial-derived peptides in metabolic regulation.” Endocrine Reviews.
https://pubmed.ncbi.nlm.nih.gov/29982658/
- Reynolds J.C. et al. “MOTS-C promotes metabolic homeostasis in experimental models.” Aging Cell.
https://pubmed.ncbi.nlm.nih.gov/29131333/
- Yen K. et al. “Mitochondrial peptides and exercise-related metabolic adaptation.” FASEB Journal.
https://pubmed.ncbi.nlm.nih.gov/30663257/
- Zarse K. et al. “Mitochondrial signaling peptides and longevity pathways.” Cell Metabolism.
https://pubmed.ncbi.nlm.nih.gov/31543416/