PT-141

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PT-141 is a synthetic cyclic heptapeptide derived from melanocortin peptide research. It is commonly referenced in neuroendocrine and receptor biology studies focused on melanocortin receptor signaling, central nervous system pathways, and peptide–receptor interactions. Supplied strictly for laboratory research use only.

For research purposes only. Not for human consumption

Research Overview

PT-141, also known as bremelanotide, functions as an agonist at melanocortin receptors, particularly MC3R and MC4R, which are involved in central nervous system signaling and neuroendocrine regulation [1]. Unlike earlier melanocortin-related peptides studied primarily for pigmentation pathways, PT-141 has been investigated for its receptor selectivity and central mechanism of action in preclinical models [2]. Molecular and pharmacological studies examine its ability to cross the blood–brain barrier and activate melanocortin pathways independent of peripheral vascular mechanisms [3]. These properties make PT-141 a valuable research compound for studying melanocortin receptor biology and CNS peptide signaling.

Applications in Scientific Research

In laboratory and animal research models, PT-141 is primarily used in neuropharmacology, endocrinology, and behavioral neuroscience research. Published studies explore its interaction with hypothalamic signaling pathways, dopaminergic modulation, and melanocortin-mediated neural circuits under controlled experimental conditions [4]. Additional research examines PT-141 in studies of receptor binding affinity, structure–activity relationships, and central versus peripheral peptide signaling differentiation [5][6]. These investigations position PT-141 as a reference peptide for researchers studying melanocortin receptor function, neuropeptide signaling, and central regulatory pathways. This compound is intended solely for research and analytical purposes and is not approved for human or veterinary use.

Referenced Citations

  1. Hadley M.E., Haskell-Luevano C. “The proopiomelanocortin system.” Annals of the New York Academy of Sciences.
    https://pubmed.ncbi.nlm.nih.gov/10415887/
  2. Kingsberg S.A. et al. “Bremelanotide for melanocortin receptor research.” Journal of Sexual Medicine.
    https://pubmed.ncbi.nlm.nih.gov/22458501/
  3. Pfaus J.G. et al. “Central melanocortin signaling mechanisms.” Neuroscience & Biobehavioral Reviews.
    https://pubmed.ncbi.nlm.nih.gov/19897080/
  4. Wessells H. et al. “Melanocortin receptor agonists and CNS pathways.” Proceedings of the National Academy of Sciences.
    https://pubmed.ncbi.nlm.nih.gov/10973474/
  5. Hruby V.J., Cai M. “Design of melanocortin receptor ligands.” Journal of Peptide Science.
    https://pubmed.ncbi.nlm.nih.gov/15593278/
  6. Mountjoy K.G. “Distribution and function of melanocortin receptors.” Annals of the New York Academy of Sciences.
    https://pubmed.ncbi.nlm.nih.gov/11894838/
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