GLP-TRZ

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It is a synthetic peptide engineered to activate both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. It is commonly referenced in metabolic and endocrine research examining dual incretin signaling and receptor-mediated cellular pathways. Supplied strictly for laboratory research use only.

For research purposes only. Not for human consumption

Research Overview

It is structurally designed to combine GIP receptor agonism with GLP-1 receptor activity, allowing researchers to study synergistic incretin signaling within controlled experimental models [1]. Preclinical and molecular studies have focused on its interaction with cAMP signaling cascades, pancreatic islet cell receptor expression, and downstream metabolic regulatory pathways [2].

Applications in Scientific Research

Additional studies have examined dual GIP/GLP-1 agonists in appetite-regulating neural pathways, lipid metabolism models, and cardiovascular signaling research [3][4]. These findings have positioned it as a key reference compound for researchers investigating incretin biology, multi-receptor peptide engineering, and complex metabolic signaling systems. This compound is intended solely for research and analytical purposes and is not approved for human or veterinary use.

Referenced Citations

  1. Coskun T. et al. “LY3298176, a novel dual GIP and GLP-1 receptor agonist.” Science Translational Medicine.
    https://pubmed.ncbi.nlm.nih.gov/30923195/
  2. Campbell J.E., Drucker D.J. “Pharmacology, physiology, and mechanisms of incretin hormone action.” Cell Metabolism.
    https://pubmed.ncbi.nlm.nih.gov/24836535/
  3. Finan B. et al. “Unimolecular dual incretins maximize metabolic benefits.” Nature Medicine.
    https://pubmed.ncbi.nlm.nih.gov/27018757/
  4. Holst J.J., Rosenkilde M.M. “GIP as a therapeutic target.” Trends in Endocrinology & Metabolism.
    https://pubmed.ncbi.nlm.nih.gov/30291044/
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