Research Overview
CJC-1295 was developed to enhance the half-life of native GHRH by incorporating structural modifications that reduce enzymatic degradation [1]. In molecular and preclinical research, CJC-1295 is used to study GHRH receptor activation, cyclic AMP signaling, and downstream regulation of growth hormone release at the pituitary level [2]. Variants of CJC-1295, including DAC (Drug Affinity Complex) forms, have been examined for their ability to bind serum albumin, allowing sustained receptor engagement in experimental models [3]. These characteristics make CJC-1295 a useful reference compound in peptide pharmacokinetics and endocrine signaling research.
Applications in Scientific Research
In laboratory and animal research models, CJC-1295 is primarily studied in endocrinology, metabolism, and aging-related research frameworks. Published literature explores its role in pulsatile growth hormone signaling, insulin-like growth factor (IGF-1) axis studies, and neuroendocrine regulation under controlled experimental conditions [4]. Additional investigations focus on structure–activity relationships of GHRH analogs and their impact on receptor selectivity and signaling duration [5][6]. These studies position CJC-1295 as a valuable tool for researchers examining growth hormone biology, peptide modification strategies, and long-acting hormone analog design. This compound is not intended for human or veterinary use.
Referenced Citations
- Teichman S.L. et al. “Prolonged stimulation of growth hormone secretion by CJC-1295.” Journal of Clinical Endocrinology & Metabolism.
https://pubmed.ncbi.nlm.nih.gov/16014408/
- Frohman L.A., Jansson J.O. “Growth hormone–releasing hormone biology.” Endocrine Reviews.
https://pubmed.ncbi.nlm.nih.gov/6316087/
- Merriam G.R. et al. “Albumin-binding growth hormone–releasing hormone analogs.” Journal of Clinical Endocrinology & Metabolism.
https://pubmed.ncbi.nlm.nih.gov/16492785/
- Giustina A. et al. “Growth hormone secretion and regulation.” Endocrine Reviews.
https://pubmed.ncbi.nlm.nih.gov/29401324/
- Bowers C.Y. “GHRH analogs and structure–activity relationships.” Peptides.
https://pubmed.ncbi.nlm.nih.gov/12048132/
- Veldhuis J.D. et al. “Neuroendocrine control of growth hormone secretion.” Physiological Reviews.
https://pubmed.ncbi.nlm.nih.gov/12794189/