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Melanotan II is a synthetic cyclic peptide analog derived from alpha-melanocyte-stimulating hormone (α-MSH). It is widely referenced in neuroendocrine and receptor biology research focused on melanocortin receptor signaling and peptide–receptor interaction studies. Supplied strictly for laboratory research use only.
For research purposes only. Not for human consumption
Melanotan II functions as a non-selective agonist of melanocortin receptors, with activity at MC1R, MC3R, MC4R, and MC5R [1]. In preclinical research, it is commonly used to study melanocortin signaling pathways involved in pigmentation biology, energy balance, and central nervous system regulation [2]. Due to its cyclic structure, Melanotan II exhibits enhanced stability compared to linear α-MSH peptides, making it a useful reference compound in receptor binding and structure–activity relationship studies [3]. Its broad receptor affinity allows researchers to examine downstream signaling cascades across multiple melanocortin receptor subtypes.
In laboratory and animal research models, Melanotan II is primarily utilized in neuropharmacology, endocrinology, and pigmentation research frameworks. Published studies investigate its role in melanocyte activation, cyclic AMP signaling, and gene expression related to melanin synthesis under controlled conditions [4]. Additional research explores Melanotan II in studies of hypothalamic signaling, appetite regulation pathways, and sexual behavior models linked to melanocortin receptor activation [5][6]. These findings position Melanotan II as a valuable research peptide for studying melanocortin receptor biology and central peptide signaling mechanisms. This compound is not intended for human or veterinary use.
