NAD+

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NAD⁺ is an essential pyridine nucleotide involved in redox reactions and cellular energy metabolism. It is widely referenced in biochemical and molecular biology research for its role in mitochondrial function, enzymatic activity, and cellular stress response pathways. Supplied strictly for laboratory research use only.

For research purposes only. Not for human consumption

Research Overview

NAD⁺ functions as a critical coenzyme in oxidation–reduction reactions, enabling electron transfer in metabolic pathways such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation [1]. Beyond its metabolic role, NAD⁺ serves as a substrate for enzymes including sirtuins, PARPs, and CD38, which are involved in DNA repair, epigenetic regulation, and cellular signaling [2][3]. Declining intracellular NAD⁺ levels have been observed in multiple experimental aging and stress models, leading to significant interest in NAD⁺ biology across cellular metabolism and longevity-related research domains.

Applications in Scientific Research

In preclinical and in vitro research, NAD⁺ is commonly studied in models examining mitochondrial dynamics, oxidative stress, and genome stability. Research has explored its role in regulating sirtuin-mediated pathways, cellular senescence models, and adaptive responses to metabolic stress [4]. Additional studies investigate NAD⁺ turnover and salvage pathways involving nicotinamide phosphoribosyltransferase (NAMPT), highlighting its importance in maintaining intracellular NAD⁺ pools [5]. These findings have positioned NAD⁺ as a foundational molecule in metabolic, neurobiological, and aging-related research. This material is intended solely for research and analytical purposes and is not approved for human or veterinary use.

Referenced Citations

  1. Ying W. “NAD⁺/NADH and NADP⁺/NADPH in cellular functions and cell death.” Frontiers in Bioscience.
    https://pubmed.ncbi.nlm.nih.gov/12700165/
  2. Imai S., Guarente L. “NAD⁺ and sirtuins in aging and disease.” Trends in Cell Biology.
    https://pubmed.ncbi.nlm.nih.gov/20005395/
  3. Bürkle A. “Poly(ADP-ribose): the most elaborate metabolite of NAD⁺.” FEBS Journal.
    https://pubmed.ncbi.nlm.nih.gov/20015068/
  4. Verdin E. “NAD⁺ in aging, metabolism, and neurodegeneration.” Science.
    https://pubmed.ncbi.nlm.nih.gov/25908863/
  5. Revollo J.R. et al. “The NAD biosynthesis pathway mediated by NAMPT.” Journal of Biological Chemistry.
    https://pubmed.ncbi.nlm.nih.gov/17923697/
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